1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
Here are the key drug-food interactions:
Cialis and Viagra sales in the United States
As the largest drug maker, Eli Lilly and Company (LLY) is in the midst of a huge merger, with the rest of the pharmaceutical industry as a partner. The pharmaceutical industry will be dominated by the drug giant as it moves into the next decade. As a result, there is more competition for market shares and sales of generic drugs.
The company has about 10 times the market for Viagra (sildenafil) and a huge market for Cialis (tadalafil), among other drugs. The companies currently market Cialis generics, and the drug market is growing at a faster rate than Viagra, which is currently the second-largest generic drug market in the world.
Lilly, which recently announced a $2.5 billion merger with Icos Corporation, was also the largest drug maker. It had more than $12 billion in revenue last year, accounting for the company’s growth.
The biggest merger came when Eli Lilly acquired the patent for its erectile dysfunction drug Cialis. In 2012, Lilly and Icos sold the rights to Cialis to a separate pharmaceutical company called Mylan. Lilly also bought Mylan for $1.8 billion in cash, according to a Wall Street Journal report. Icos and Lilly then filed a new lawsuit against Lilly in federal court in New York. It argued that Lilly was trying to block the merger and the company would benefit from the merger.
The lawsuit, filed in state court in the Western States, alleges that Lilly’s efforts to block the merger were fraudulent and in violation of the Securities and Exchange Commission Act. The complaint is that Eli Lilly has intentionally and fraudulently failed to secure a specific payment to Lilly, and then hid this payment to the company to maximize the profits of the merger.
The lawsuit seeks to force Lilly to take advantage of the merger and the merger-related expenses that it would otherwise pay to Icos and Mylan. The lawsuit alleges that Lilly’s attempt to block the merger violated federal antitrust laws and that the alleged kickback scheme was anticompetitive. The complaint alleges that Lilly had failed to provide adequate notice of the merger’s intent to defraud the public and that the company was intentionally promoting the merger.
According to the complaint, a “substantial benefit” to Lilly was that its merger would result in $1.1 billion of the company’s $6.9 billion in future sales, as well as $3.5 billion in revenue.
Lilly’s executives have also alleged that the company was trying to maximize the profit margins and profits of the merger. The suit alleges that Lilly’s executives “improperly engaged in a scheme to conceal or delay the approval of [the merger] to maximize the financial benefit to [Lilly] to promote their product” and to “defraud the public.”
Lilly’s executives have also alleged that Lilly’s executives were intentionally promoting the merger as a “bonus” in order to “maintain profits.”
The complaint says that Lilly’s executives “improperly engaged in a scheme to conceal or delay the approval of [the merger] to maximize the financial benefit to [Lilly].”
Lilly has been sued for allegedly illegally promoting the merger as a “bonus.”
It also contends that the company was engaged in a scheme to hide the value of its product, and the company failed to properly report the value of its product to the market.
In April 2012, Eli Lilly agreed to pay $1.9 billion to settle claims that the company illegally promoted its erectile dysfunction drug Viagra. The company paid $1.5 billion to settle claims that the drug was being used to treat an “inability to achieve, maintain, or achieve orgasm.”
The lawsuit claims that Lilly violated the federal Securities Act by making false and misleading claims about the drug’s effectiveness and safety, and by marketing Viagra for a non-medical purpose.
Lilly and Icos also agreed to settle a class-action lawsuit filed by men who were diagnosed with erectile dysfunction (ED) or other medical conditions that affect sexual function.
Lilly and Icos are currently facing lawsuits by more than 1,300 men.
Lilly, which began in 1996, is the largest pharmaceutical company in the U. S. and was the second largest drug company in the world.
Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.
You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.
There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-
• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).
• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets
for chest pain or use Rectogesic ointment?
• Nicorandil (Ikorel), used to treat angina
• Cimetidine, used to treat stomach or duodenal (peptic) ulcers
• Theophylline, used to treat asthma
• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin
• Anti-fungals such as itraconazole and ketoconazole
• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone
• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide
• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat
• Recreational drugs:- amyl nitrate (poppers)
If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.
Read available consultation questionnaire informationYou can increase the dosage of your other medications by contact person with patients questions starting from the very beginning and getting more detailed information about each medication.
The maximum up to out-of-hours dose for Tadalafil may not be disclosed but can be increased by, if you want to take Tadalafil only with medicines that you usually take daily or out of the hospital (even if you are still sick).
You can take Tadalafil with or without food.
You can take Tadalafil with any medicine except medicines that■Take Tadalafil with Vitamin Busional medicines such as,,,,, which may be used to treat prostate problems or high blood pressure or Flomax
You should take Tadalafil with a food or water delayed-release tablet or a suspension
You can take Tadalafil with any antibiotic and some other antibiotics such as erythromycin and ciprofloxacin
It is not known if Tadalafil should be taken more than once in a day, or how long Tadalafil should be taken. Please, consult your GP or a specialist provider who can discuss your medical history and current medicines.
You should not take Tadalafil if you are pregnant or trying to become pregnant, or if you are breastfeeding. Talk to your GP or a healthcare professional if you have questions about this and you have your doctor or pharmacist available to answer your questions.
Your GP or a healthcare provider should not take Tadalafil if you are pregnant or trying to become pregnant.
Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.
Sildenafil is available in 25mg, 50mg, and 100mg strengths.
Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.
Common side effects include:
Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.
Sildenafil should not be used by those:
Inform your doctor of all medications and supplements before use. Interactions may occur with:
Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.
Sildenafil is available by prescription only in the UK.
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